| http://purl.uniprot.org/citations/30061678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30061678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30061678 | http://www.w3.org/2000/01/rdf-schema#comment | "Individuals can vary substantially in size, but the proportions of their body plans are often maintained. We generated smaller zebrafish by removing 30% of their cells at the blastula stages and found that these embryos developed into normally patterned individuals. Strikingly, the proportions of all germ layers adjusted to the new embryo size within 2 hours after cell removal. As Nodal-Lefty signalling controls germ-layer patterning, we performed a computational screen for scale-invariant models of this activator-inhibitor system. This analysis predicted that the concentration of the highly diffusive inhibitor Lefty increases in smaller embryos, leading to a decreased Nodal activity range and contracted germ-layer dimensions. In vivo studies confirmed that Lefty concentration increased in smaller embryos, and embryos with reduced Lefty levels or with diffusion-hindered Lefty failed to scale their tissue proportions. These results reveal that size-dependent inhibition of Nodal signalling allows scale-invariant patterning."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41556-018-0155-7"xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Muller P."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Muller P."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Schier A.F."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Schier A.F."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Marcon L."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Marcon L."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Rogers K.W."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Rogers K.W."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Almuedo-Castillo M."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Almuedo-Castillo M."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Blassle A."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Blassle A."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Morsdorf D."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Morsdorf D."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Soh G.H."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/author | "Soh G.H."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30061678 | http://purl.uniprot.org/core/pages | "1032-1042"xsd:string |