| http://purl.uniprot.org/citations/30063210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30063210 | http://www.w3.org/2000/01/rdf-schema#comment | "During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Rap2 GTPase (rap-2) and its effector, TNIK (mig-15), act genetically downstream of Plexin (plx-1) to restrict presynaptic assembly and to form tiled synaptic innervation in C. elegans. Both constitutively GTP- and GDP-forms of rap-2 mutants exhibit synaptic tiling defects as plx-1 mutants, suggesting that cycling of the RAP-2 nucleotide state is critical for synapse inhibition. Consistently, PLX-1 suppresses local RAP-2 activity. Excessive ectopic synapse formation in mig-15 mutants causes a severe synaptic tiling defect. Conversely, overexpression of mig-15 strongly inhibited synapse formation, suggesting that mig-15 is a negative regulator of synapse formation. These results reveal that subcellular regulation of small GTPase activity by Plexin shapes proper synapse patterning in vivo."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.38801"xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Mizumoto K."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Murakoshi H."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Kurashina M."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "MacVicar B.A."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Hendi A."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Weilinger N.L."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Fortes E."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/author | "Shibata A.C."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/pages | "e38801"xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/title | "Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/30063210 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30063210 |
| http://purl.uniprot.org/citations/30063210 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30063210 |
| http://purl.uniprot.org/uniprot/P10114#attribution-15BE035A11B8F6E1FFA19873CBD11CBA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30063210 |
| http://purl.uniprot.org/uniprot/#_Q18246-mappedCitation-30063210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30063210 |
| http://purl.uniprot.org/uniprot/#_Q23356-mappedCitation-30063210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30063210 |
| http://purl.uniprot.org/uniprot/#_O01312-mappedCitation-30063210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30063210 |
| http://purl.uniprot.org/uniprot/#_O17599-mappedCitation-30063210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30063210 |
| http://purl.uniprot.org/uniprot/#_Q3V5K0-mappedCitation-30063210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30063210 |