| http://purl.uniprot.org/citations/30067971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30067971 | http://www.w3.org/2000/01/rdf-schema#comment | "In response to activation, CD4+ T cells upregulate autophagy. However, the functional consequences of that upregulation have not been fully elucidated. In this study, we identify autophagy as a tolerance-avoidance mechanism. Our data show that inhibition of autophagy during CD4+ T cell activation induces a long-lasting state of hypo-responsiveness that is accompanied by the expression of an anergic gene signature. Cells unable to induce autophagy after T cell receptor (TCR) engagement show inefficient mitochondrial respiration and decreased turnover of the protein tyrosine phosphatase PTPN1, which translates into defective TCR-mediated signaling. In vivo, inhibition of autophagy during antigen priming induces T cell anergy and decreases the severity of disease in an experimental autoimmune encephalomyelitis mouse model. Interestingly, CD4+ T cells isolated from the synovial fluid of juvenile idiopathic arthritis patients, while resistant to suboptimal stimulation-induced anergy, can be tolerized with autophagy inhibitors. We propose that autophagy constitutes a tolerance-avoidance mechanism, which determines CD4+ T cell fate."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.06.065"xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Coffer P.J."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Mocholi E."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Macian F."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Shafit-Zagardo B."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Ray A.K."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Gruber R.C."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Botbol Y."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Dowling S.D."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/author | "Vastert S."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/pages | "1136-1150"xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/title | "Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy."xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/30067971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30067971 |
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| http://purl.uniprot.org/uniprot/#_B5B2Q2-mappedCitation-30067971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30067971 |