| http://purl.uniprot.org/citations/30070972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30070972 | http://www.w3.org/2000/01/rdf-schema#comment | "Since early diagnosis is very important for treating CRC, we decided to detect peripheral serum canopy fibroblast growth factor signaling regulator 2 (CNPY2) isoform 2 to verify its diagnostic value for CRC patients. Serum samples were collected from 430 CRC patients and 201 healthy controls. Enzyme-linked immunosorbent assay (ELISA) detection kits for CNPY2 isoform 2 were generated and then applied to measure serum CNPY2 isoform 2 concentrations. Serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were also measured. The median serum CNPY2 isoform 2 concentrations in all CRC patients were significantly higher than those in the healthy control group (all P<0.001). Those with stage I CRC presented the highest area under the receiver operating characteristic curve (AUC) for CNPY2 isoform 2 [0.707, 95% confidence interval (CI): 0.649-0.765, P<0.001]. The diagnostic efficiency of the combination of CNPY2 isoform 2, CEA and CA19-9 was significantly higher than that of each biomarker detected separately (all P<0.0167). Serum CNPY2 isoform 2 may be a valuable biomarker for the early detection of CRC and presents an improvement in the diagnostic efficiency by combination of CEA and CA19-9."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.101512"xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Fang Y."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Wan D."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Ou Q."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/author | "Pan Z."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/pages | "1921-1931"xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/title | "Serum CNPY2 isoform 2 represents a novel biomarker for early detection of colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30070972 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30070972 |
| http://purl.uniprot.org/citations/30070972 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30070972 |
| http://purl.uniprot.org/uniprot/#_A0A024R0K5-mappedCitation-30070972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30070972 |
| http://purl.uniprot.org/uniprot/#_Q13984-mappedCitation-30070972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30070972 |