| http://purl.uniprot.org/citations/30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30072438 | http://www.w3.org/2000/01/rdf-schema#comment | "The endo-lysosomal network serves an essential role in determining the fate of endocytosed transmembrane proteins and their associated proteins and lipids. Sorting nexins (SNXs) play a central role in the functional organisation of this network. Comprising over 30 proteins in humans, SNXs are classified into sub-groups based on the presence of additional functional domains. Sorting nexin-20 (SNX20) and sorting nexin-21 (SNX21) comprise the SNX-PXB proteins. The presence of a predicted protein-protein interaction domain, termed the PX-associated B (PXB) domain, has led to the proposal that they function as endosome-associated scaffolds. Here, we used unbiased quantitative proteomics to define the SNX21 interactome. We reveal that the N-terminal extension of SNX21 interacts with huntingtin (Htt) whereas the PXB domain appears to associate with septins, a family of cytoskeletal- and membrane-associated proteins. In establishing that these interactions are sufficient for SNX21 to recruit Htt and septins on to an endosomal population, we reveal a scaffolding function for this sorting nexin. Our work paves the way for a more-detailed mechanistic analysis of the role(s) of the SNX-PXB proteins in endosomal biology."xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.211672"xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/author | "Heesom K.J."xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/author | "Cullen P.J."xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/author | "Danson C.M."xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/author | "Pearson N."xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/pages | "jcs211672"xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/title | "Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin."xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/30072438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30072438 |
| http://purl.uniprot.org/citations/30072438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30072438 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z632-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z5T2-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_A8K3C9-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTD2-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTD4-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTD5-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTD6-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTD7-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTD8-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTD9-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |
| http://purl.uniprot.org/uniprot/#_D2CTE1-mappedCitation-30072438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30072438 |