| http://purl.uniprot.org/citations/30081046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30081046 | http://www.w3.org/2000/01/rdf-schema#comment | "For Parkinson's disease (PD), the regulatory mechanism of α-synuclein (α-syn) aggregation remains to be clarified. Ubiquitination modification is crucial for α-syn aggregation, with implications for Lewy body formation. Besides, ubiquitin ligase absentia homolog (siAH) is involved in the ubiquitination of α-syn. We investigated whether the p75 receptor can act as a potential regulator of α-syn accumulation through ubiquitination. Western blot, immunoprecipitation, gene transfection, and RNA interference technology were employed to detect the effect of p75 in in vivo and in vitro models. In a rotenone-based stereotactic (ST) infusion in vivo model of PD, p75 receptor and siAH expression was increased significantly compared with the control group. In cellular models of rotenone-mediated neurotoxicity, the interactions between p75 and siAH were revealed by immunoprecipitation; the colocalization of p75 with α-syn was observed in the cytoplasm; p75 promoted nuclear expression of NF-κB (p65), which might interact with the promoter of the siAH gene. Moreover, siRNA-mediated p75 depletion reduced the upregulation of α-syn and nuclear expression of p65 and protected against cell apoptosis induced by rotenone. Thus, aberrant expression of p75 may regulate the increased expression of α-syn, which is related to siAH-mediated ubiquitination and nuclear expression of p65."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2018.07.048"xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Hou Y."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Ge R."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/author | "Du R."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/pages | "367-373"xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/title | "P75 Involved in the Ubiquitination of alpha-synuclein in Rotenone-based Parkinson's Disease Models."xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://purl.uniprot.org/core/volume | "388"xsd:string |
| http://purl.uniprot.org/citations/30081046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30081046 |
| http://purl.uniprot.org/citations/30081046 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30081046 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTN7-mappedCitation-30081046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30081046 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HU10-mappedCitation-30081046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30081046 |
| http://purl.uniprot.org/uniprot/#_A6HIA5-mappedCitation-30081046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30081046 |
| http://purl.uniprot.org/uniprot/#_A6KF04-mappedCitation-30081046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30081046 |
| http://purl.uniprot.org/uniprot/#_A6KF07-mappedCitation-30081046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30081046 |
| http://purl.uniprot.org/uniprot/#_B5A977-mappedCitation-30081046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30081046 |