| http://purl.uniprot.org/citations/30084827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30084827 | http://www.w3.org/2000/01/rdf-schema#comment | "HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we show that HIV-1 CA can bind multiple Nups, and that both natural and manipulated variation in Nup levels impacts HIV-1 infection in a manner that is strikingly dependent on cell-type, cell-cycle, and cyclophilin A (CypA). We also show that Nups mediate the function of the antiviral protein MX2, and that MX2 can variably inhibit non-viral NLS function. Remarkably, both enhancing and inhibiting effects of cyclophilin A and MX2 on various HIV-1 CA mutants could be induced or abolished by manipulating levels of the Nup93 subcomplex, the Nup62 subcomplex, NUP88, NUP214, RANBP2, or NUP153. Our findings suggest that several Nup-dependent 'pathways' are variably exploited by HIV-1 to target host DNA in a cell-type, cell-cycle, CypA and CA-sequence dependent manner, and are differentially inhibited by MX2."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.35738"xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/author | "Kvaratskhelia M."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/author | "Yamashita M."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/author | "Bieniasz P.D."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/author | "Kane M."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/author | "Rebensburg S.V."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/author | "Zang T.M."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/author | "Takata M.A."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/pages | "e35738"xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/title | "Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2."xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/30084827 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30084827 |
| http://purl.uniprot.org/citations/30084827 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30084827 |
| http://purl.uniprot.org/uniprot/#_A0A288CG13-mappedCitation-30084827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084827 |
| http://purl.uniprot.org/uniprot/#_Q75MY7-mappedCitation-30084827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084827 |
| http://purl.uniprot.org/uniprot/#_Q75MY8-mappedCitation-30084827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084827 |
| http://purl.uniprot.org/uniprot/#_P04591-mappedCitation-30084827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084827 |
| http://purl.uniprot.org/uniprot/#_P20592-mappedCitation-30084827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084827 |
| http://purl.uniprot.org/uniprot/#_Q77YG1-mappedCitation-30084827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084827 |
| http://purl.uniprot.org/uniprot/Q75MY7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30084827 |
| http://purl.uniprot.org/uniprot/P20592 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30084827 |