| http://purl.uniprot.org/citations/30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30084950 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian dorsal telencephalic neuroepithelium develops-from medial to lateral-into the choroid plaque, cortical hem, hippocampal primordium and isocortex under the influence of Bmp, Wnt and Notch signaling. Correct telencephalic development requires a tight coordination of the extent/duration of these signals, but the identification of possible molecular coordinators is still limited. Here, we postulated that Secreted Frizzled Related Protein 1 (Sfrp1), a multifunctional regulator of Bmp, Wnt and Notch signaling strongly expressed during early telencephalic development, may represent 1 of such molecules. We report that in E10.5-E12.5 Sfrp1-/-embryos, the hem and hippocampal domains are reduced in size whereas the prospective neocortex is medially extended. These changes are associated with a significant reduction of the medio-lateral telencephalic expression of Axin2, a read-out of Wnt/βcatenin signaling activation. Furthermore, in the absence of Sfrp1, Notch signaling is increased, cortical progenitor cell cycle is shorter, with expanded progenitor pools and enhanced generation of early-born neurons. Hence, in postnatal Sfrp1-/-animals the anterior hippocampus is reduced and the neocortex is shorter in the antero-posterior and medio-lateral axis but is thicker. We propose that, by controlling Wnt and Notch signaling in opposite directions, Sfrp1 promotes hippocampal patterning and balances medio-lateral and antero-posterior cortex expansion."xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhy013"xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/author | "Crespo I."xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/author | "Bovolenta P."xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/author | "Esteve P."xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/author | "Sandonis A."xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/author | "Kaimakis P."xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/name | "Cereb Cortex"xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/pages | "1059-1074"xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/title | "Sfrp1 Modulates Cell-signaling Events Underlying Telencephalic Patterning, Growth and Differentiation."xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/30084950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30084950 |
| http://purl.uniprot.org/citations/30084950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30084950 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDX9-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQK9-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_P63015-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRX1-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_A2AR81-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF61-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |
| http://purl.uniprot.org/uniprot/#_A2A409-mappedCitation-30084950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30084950 |