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http://purl.uniprot.org/citations/30087323http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30087323http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30087323http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30087323http://www.w3.org/2000/01/rdf-schema#comment"The Group B streptococcus (GBS) can express a capsular polysaccharide (CPS). There are ten recognized CPSs (Ia, Ib, and II-IX). A GBS isolate is considered nontypeable (NT) when CPS cannot be identified as one of ten types. Two groups of GBS NT isolates were studied, isolates without surface sialic acid (sia(-)) and isolates with surface sialic acid (sia(+)). The first objective was to characterize NT sia(-) isolates that failed CPS identification by an immunodiffusion antisera typing assay and a RT-PCR capsule typing assay. NT sia(-) isolates were characterized by assaying phenotypic changes and identifying covR/S mutations that may potentially have a role in the altered phenotypes. The second objective was to characterize NT sia(+) isolates that failed to identify as one of the ten CPS types by an immundiffusion antisera-based typing assay and a RT-PCR capsule typing assay yet expressed capsule. Fifteen NT sia(-) isolates displayed increased β hemolysis/orange pigmentation, decreased CAMP activity, inability to form biofilm, and susceptibility to phagocytosis by human blood. DNA sequence analysis of the covR/S genes in the sia(-) isolates found mutations in 14 of 15 isolates assayed. These mutations in the covR/S genes may potentially contribute to lack of expression of phenotypic traits assayed in vitro. For the three NT sia(+) isolates, whole-genome sequence analyses identified two isolates with cps gene clusters identical to the recently described and uncommon CPSIIa type. The third isolate possessed a hybrid cluster containing cps genes for both CPSIIa and CPSV suggesting recombination between these two gene clusters."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.org/dc/terms/identifier"doi:10.1038/s41426-018-0138-6"xsd:string
http://purl.uniprot.org/citations/30087323http://purl.org/dc/terms/identifier"doi:10.1038/s41426-018-0138-6"xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/author"Tyrrell G.J."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/author"Tyrrell G.J."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/author"Tyrrell G.J."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/author"Alhhazmi A."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/author"Alhhazmi A."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/author"Alhhazmi A."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/name"Emerg. Microbes Infect."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/name"Emerg Microbes Infect"xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/name"Emerg Microbes Infect"xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/pages"137"xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/pages"137"xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/pages"137"xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/title"Phenotypic and molecular analysis of nontypeable Group B streptococci: identification of cps2a and hybrid cps2a/cps5 Group B streptococcal capsule gene clusters."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/title"Phenotypic and molecular analysis of nontypeable Group B streptococci: identification of cps2a and hybrid cps2a/cps5 Group B streptococcal capsule gene clusters."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/title"Phenotypic and molecular analysis of nontypeable Group B streptococci: identification of cps2a and hybrid cps2a/cps5 Group B streptococcal capsule gene clusters."xsd:string
http://purl.uniprot.org/citations/30087323http://purl.uniprot.org/core/volume"7"xsd:string
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