http://purl.uniprot.org/citations/30087345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/30087345 | http://www.w3.org/2000/01/rdf-schema#comment | "The cerebellum integrates descending motor commands and sensory information to generate predictions and detect errors during ongoing behaviors. Cerebellar computation has been proposed to control motor but also non-motor behaviors, including reward expectation and cognitive flexibility. However, the organization and functional contribution of cerebellar output channels are incompletely understood. Here, we elaborate the cell-type specificity of a broad connectivity matrix from the deep cerebellar nuclei (DCN) to the dorsal striatum in mice. Cerebello-striatal connections arise from all deep cerebellar subnuclei and are relayed through intralaminar thalamic nuclei (ILN). In the dorsal striatum, these connections target medium spiny neurons, but also ChAT-positive interneurons, a class of tonically active interneurons implicated in shifting and updating behavioral strategies. Chemogenetic silencing of cerebello-striatal connectivity modifies function of striatal ChAT-positive interneurons. We propose that cerebello-striatal connections relay cerebellar computation to striatal circuits for goal-directed behaviors."xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-05565-y"xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/author | "Xiao L."xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/author | "Scheiffele P."xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/author | "Bornmann C."xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/author | "Hatstatt-Burkle L."xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/pages | "3133"xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/title | "Regulation of striatal cells and goal-directed behavior by cerebellar outputs."xsd:string |
http://purl.uniprot.org/citations/30087345 | http://purl.uniprot.org/core/volume | "9"xsd:string |
http://purl.uniprot.org/citations/30087345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30087345 |
http://purl.uniprot.org/citations/30087345 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30087345 |
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http://purl.uniprot.org/uniprot/#_Q8BLE7-mappedCitation-30087345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30087345 |
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