| http://purl.uniprot.org/citations/30089223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30089223 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelet activity is regulated by a number of surface expressed G protein-coupled receptors (GPCRs) including the α isoform of the thromboxane receptor (TPα receptor). With the advance of genomic technologies, there has been a substantial increase in the identification of naturally occurring rare GPCR variants including in the TBXA2R gene, which encodes the TPα receptor. The study of patients with naturally occurring variants within TBXA2R associated with bleeding and abnormal TPα receptor function has provided a powerful insight in defining the critical role of TPα in thrombus formation. This review will highlight how the identification of these function-disrupting variants of the platelet TPα has contributed important structure-function information about these GPCRs. Further we discuss the potential implications these findings have for understanding the molecular basis of mild platelet based bleeding disorders."xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://purl.org/dc/terms/identifier | "doi:10.1080/09537104.2018.1499888"xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://purl.uniprot.org/core/author | "Mundell S.J."xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://purl.uniprot.org/core/author | "Mumford A."xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30089223 | http://purl.uniprot.org/core/name | "Platelets"xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://purl.uniprot.org/core/pages | "739-742"xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://purl.uniprot.org/core/title | "TBXA2R gene variants associated with bleeding."xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/30089223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30089223 |
| http://purl.uniprot.org/citations/30089223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30089223 |
| http://purl.uniprot.org/uniprot/#_P21731-mappedCitation-30089223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30089223 |
| http://purl.uniprot.org/uniprot/#_Q05C92-mappedCitation-30089223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30089223 |
| http://purl.uniprot.org/uniprot/#_Q0VAA9-mappedCitation-30089223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30089223 |
| http://purl.uniprot.org/uniprot/#_Q0VAB0-mappedCitation-30089223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30089223 |
| http://purl.uniprot.org/uniprot/P21731 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30089223 |
| http://purl.uniprot.org/uniprot/Q05C92 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30089223 |
| http://purl.uniprot.org/uniprot/Q0VAB0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30089223 |
| http://purl.uniprot.org/uniprot/Q0VAA9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30089223 |