| http://purl.uniprot.org/citations/30093112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30093112 | http://www.w3.org/2000/01/rdf-schema#comment | "Blocking aerobic glycolysis has been proposed as an attractive therapeutic strategy for impairing the proliferation of cancer cells. However, the underlying mechanisms are poorly understood. Here, we show that miR-15b-5p was downregulated in osteosarcoma (OS) and that lower expression of miR-15b-5p promoted proliferation and contributed to the Warburg effect in OS cells. Mechanistically, miR-15b-5p acted as a tumor suppressor in OS by directly targeting pyruvate dehydrogenase kinase-4 and inhibiting its expression. These results reveal a previously unknown function of miR-15b-5p in OS, which is associated with metabolic alterations that promote cancer progression. miR-15b-5p may play an essential role in the molecular therapy of patients with OS."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.08.035"xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Pan X."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Kong F."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/author | "Weng Y."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/pages | "2749-2757"xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/title | "The miR-15b-5p/PDK4 axis regulates osteosarcoma proliferation through modulation of the Warburg effect."xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://purl.uniprot.org/core/volume | "503"xsd:string |
| http://purl.uniprot.org/citations/30093112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30093112 |
| http://purl.uniprot.org/citations/30093112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30093112 |
| http://purl.uniprot.org/uniprot/#_A4D1H4-mappedCitation-30093112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093112 |
| http://purl.uniprot.org/uniprot/#_B3KU25-mappedCitation-30093112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093112 |
| http://purl.uniprot.org/uniprot/#_B3KUX1-mappedCitation-30093112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093112 |