| http://purl.uniprot.org/citations/30093645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30093645 | http://www.w3.org/2000/01/rdf-schema#comment | "Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by an autoimmune reaction to hepatocytes. A single nucleotide polymorphism in the 3' untranslated region of HLA-DPB1, rs9277534, is associated with HLA-DPB1 expression. rs9277534 has been linked to hepatitis B virus recovery/persistence and the risk of graft-versus-host disease with HLA-DPB1 mismatching transplantation of hematopoietic cells, but its role along with that of HLA-DP expression in AIH have not been fully clarified. We genotyped rs9277534 in 146 Japanese patients with AIH and 326 healthy subjects. HLA-DPB1 expression was determined by quantitative PCR. HLA-DPB1 expression was significantly higher for rs9277534G than for rs9277534A (P < 0.05). rs9277534 genotype was in strong linkage disequilibrium with the HLA-DPB1 allele (pairwise D' = 0.82-1.00). Although HLA-DP alleles were not significantly associated with AIH, the frequency of the rs9277534G allele was significantly higher in AIH patients compared with healthy subjects (P = 0.002, odds ratio [OR] = 1.56). Logistic regression analysis revealed that the HLA-DRB1*04:05 allele (P < 0.001, OR = 4.61) and rs9277534 (P = 0.004, OR = 1.67) were independently associated with AIH susceptibility. rs9277534G in the HLA-DP gene is an eQTL that affects gene expression and may contribute to AIH susceptibility."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-30406-9"xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/author | "Umemura T."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/author | "Tanaka E."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/author | "Yamazaki T."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/author | "Ota M."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/author | "Yoshizawa K."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/author | "Joshita S."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/pages | "11924"xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/title | "A cis-eQTL of HLA-DPB1 Affects Susceptibility to Type 1 Autoimmune Hepatitis."xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30093645 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30093645 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-30093645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093645 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C550-mappedCitation-30093645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093645 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C854-mappedCitation-30093645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093645 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C855-mappedCitation-30093645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093645 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C8P5-mappedCitation-30093645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30093645 |