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| http://purl.uniprot.org/citations/30093910 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear receptor RXRα (retinoid X receptor-α) is a transcription factor that regulates the expression of multiple genes. Its non-genomic function is largely related to its structure, polymeric forms and modification. Previous research revealed that some non-genomic activity of RXRα occurs via formation of heterodimers with Nur77. RXRα-Nur77 heterodimers translocate from the nucleus to the mitochondria in response to certain apoptotic stimuli and this activity correlates with cell apoptosis. More recent studies revealed a significant role for truncated RXRα (tRXRα), which interacts with the p85α subunit of the PI3K/AKT signaling pathway, leading to enhanced activation of AKT and promoting cell growth in vitro and in animals. We recently reported on a series of NSAID sulindac analogs that can bind to tRXRα through a unique binding mechanism. We also identified one analog, K-80003, which can inhibit cancer cell growth by inducing tRXRα to form a tetramer, thus disrupting p85α-tRXRα interaction. This review analyzes the non-genomic effects of RXRα in normal and tumor cells, and discusses the functional differences based on RXRα protein structure (structure source: the RCSB Protein Data Bank)."xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.org/dc/terms/identifier | "doi:10.1186/s11658-018-0103-3"xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/name | "Cell Mol Biol Lett"xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/pages | "36"xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/title | "Overview of the structure-based non-genomic effects of the nuclear receptor RXRalpha."xsd:string |
| http://purl.uniprot.org/citations/30093910 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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