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Background

A new treatment for androgenetic alopecia (AGA) is a 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth.

Objective

The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with AGA.

Methods

Twenty-three patients with AGA were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected.

Results

Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed.

Conclusion

The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with AGA. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/β-catenin or IGF-1 expression."xsd:string
http://purl.uniprot.org/citations/30096107http://purl.org/dc/terms/identifier"doi:10.1097/dss.0000000000001619"xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/author"Poovorawan Y."xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/author"Meephansan J."xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/author"Ponnikorn S."xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/author"Suchonwanit P."xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/author"Ungpraphakorn N."xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/name"Dermatol Surg"xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/pages"1295-1303"xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/title"Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/beta-Catenin in Androgenetic Alopecia."xsd:string
http://purl.uniprot.org/citations/30096107http://purl.uniprot.org/core/volume"44"xsd:string
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