| http://purl.uniprot.org/citations/30097292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30097292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30097292 | http://www.w3.org/2000/01/rdf-schema#comment | "Characterizing polyclonal antibody responses via currently available methods is inherently complex and difficult. Mapping epitopes in an immune response is typically incomplete, which creates a barrier to fully understanding the humoral response to antigens and hinders rational vaccine design efforts. Here, we describe a method of characterizing polyclonal responses by using electron microscopy, and we applied this method to the immunization of rabbits with an HIV-1 envelope glycoprotein vaccine candidate, BG505 SOSIP.664. We detected known epitopes within the polyclonal sera and revealed how antibody responses evolved during the prime-boosting strategy to ultimately result in a neutralizing antibody response. We uncovered previously unidentified epitopes, including an epitope proximal to one recognized by human broadly neutralizing antibodies as well as potentially distracting non-neutralizing epitopes. Our method provides an efficient and semiquantitative map of epitopes that are targeted in a polyclonal antibody response and should be of widespread utility in vaccine and infection studies."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.07.009"xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2018.07.009"xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Cottrell C.A."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Cottrell C.A."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Oyen D."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Oyen D."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Ward A.B."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Ward A.B."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Burton D.R."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Burton D.R."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Turner H.L."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Turner H.L."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "McCoy L.E."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "McCoy L.E."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Bianchi M."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Bianchi M."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Pauthner M."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Pauthner M."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Bastidas R."xsd:string |
| http://purl.uniprot.org/citations/30097292 | http://purl.uniprot.org/core/author | "Bastidas R."xsd:string |