| http://purl.uniprot.org/citations/30097701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30097701 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNA (miRNA)-mediated gene regulation contributes to liver pathophysiology, including hepatic stellate cell (HSC) activation and fibrosis progression. Here, we investigated the role of miR-942 in human liver fibrosis. The expression of miR-942, HSC activation markers, transforming growth factor-beta pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI), as well as collagen deposition, were investigated in 100 liver specimens from patients with varying degree of hepatitis B virus (HBV)-related fibrosis. Human primary HSCs and the immortalized cell line (LX2 cells) were used for functional studies. We found that miR-942 expression was upregulated in activated HSCs and correlated inversely with BAMBI expression in liver fibrosis progression. Transforming growth factor beta (TGF-β) and lipopolyssacharide (LPS), two major drivers of liver fibrosis and inflammation, induce miR-942 expression in HSCs via Smad2/3 respective NF-κB/p50 binding to the miR-942 promoter. Mechanistically, the induced miR-942 degrades BAMBI mRNA in HSCs, thereby sensitizing the cells for fibrogenic TGF-β signaling and also partly mediates LPS-induced proinflammatory HSC fate. In conclusion, the TGF-β and LPS-induced miR-942 mediates HSC activation through downregulation of BAMBI in human liver fibrosis. Our study provides new insights on the molecular mechanism of HSC activation and fibrosis."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00204-018-2278-9"xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Tao L."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Shen D."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Pan K."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Seki E."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Dooley S."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/author | "Nwosu Z.C."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/name | "Arch Toxicol"xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/pages | "2935-2946"xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/title | "MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/30097701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30097701 |
| http://purl.uniprot.org/citations/30097701 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30097701 |
| http://purl.uniprot.org/uniprot/#_A8K3M4-mappedCitation-30097701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30097701 |