| http://purl.uniprot.org/citations/30104346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30104346 | http://www.w3.org/2000/01/rdf-schema#comment | "Collapsed replication forks, which are a major source of DNA double-strand breaks (DSBs), are repaired by sister chromatid recombination (SCR). The Mre11-Rad50-Nbs1 (MRN) protein complex, assisted by CtIP/Sae2/Ctp1, initiates SCR by nucleolytically resecting the single-ended DSB (seDSB) at the collapsed fork. The molecular architecture of the MRN intercomplex, in which zinc hooks at the apices of long Rad50 coiled-coils connect two Mre112-Rad502 complexes, suggests that MRN also structurally assists SCR. Here, Rad50 ChIP assays in Schizosaccharomyces pombe show that MRN sequentially localizes with the seDSB and sister chromatid at a collapsed replication fork. Ctp1, which has multivalent DNA-binding and DNA-bridging activities, has the same DNA interaction pattern. Provision of an intrachromosomal repair template alleviates the nonnucleolytic requirement for MRN to repair the broken fork. Mutations of zinc-coordinating cysteines in the Rad50 hook severely impair SCR. These data suggest that the MRN complex facilitates SCR by linking the seDSB and sister chromatid."xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1808189115"xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/author | "Limbo O."xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/author | "Russell P."xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/pages | "8793-8798"xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/title | "Mre11 complex links sister chromatids to promote repair of a collapsed replication fork."xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/30104346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30104346 |
| http://purl.uniprot.org/citations/30104346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30104346 |
| http://purl.uniprot.org/uniprot/O74986#attribution-06C2293C65DF6D01AD2D9FC1A057A0F1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/O74986#attribution-73699FC27EFBDD130C6CBFFABD201E3A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/Q9UTJ8#attribution-06C2293C65DF6D01AD2D9FC1A057A0F1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/Q9UTJ8#attribution-4799D799E2F5FBE022FC930D0536A4D6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/Q9UTJ8#attribution-73699FC27EFBDD130C6CBFFABD201E3A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/P36592#attribution-73699FC27EFBDD130C6CBFFABD201E3A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/#_O14350-mappedCitation-30104346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/#_Q9UTJ8-mappedCitation-30104346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/Q9UTJ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30104346 |
| http://purl.uniprot.org/uniprot/O14350 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30104346 |