| http://purl.uniprot.org/citations/30115930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30115930 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription and replication. The gamma isoform of IL-32 (IL-32γ) inhibits viral enhancer activities by downregulating liver-enriched transcription factors. Our data are validated in both an in vivo HBV mouse model and primary human hepatocytes. This study thus suggests that IL-32γ functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-05782-5"xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Kim D.S."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Park Y.K."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Kang H.S."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Lee A.R."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Song M.J."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Ahn S.H."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Kim K.H.'"xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Chung W.C."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Park E.S."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Won J.H."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Ha Y.N."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/author | "Jae B."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/pages | "3284"xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/title | "Intracellular interleukin-32gamma mediates antiviral activity of cytokines against hepatitis B virus."xsd:string |
| http://purl.uniprot.org/citations/30115930 | http://purl.uniprot.org/core/volume | "9"xsd:string |