| http://purl.uniprot.org/citations/30116787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30116787 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium (Ca2+) plays a major role in numerous physiological processes. Ca2+ homeostasis is tightly controlled by ion channels, the aberrant regulation of which results in various diseases including cancers. Calmodulin (CaM)-mediated Ca2+-induced inactivation is an ion channel regulatory mechanism that protects cells against the toxic effects of Ca2+ overload. We used cryo-electron microscopy to capture the epithelial calcium channel TRPV6 (transient receptor potential vanilloid subfamily member 6) inactivated by CaM. The TRPV6-CaM complex exhibits 1:1 stoichiometry; one TRPV6 tetramer binds both CaM lobes, which adopt a distinct head-to-tail arrangement. The CaM carboxyl-terminal lobe plugs the channel through a unique cation-π interaction by inserting the side chain of lysine K115 into a tetra-tryptophan cage at the pore's intracellular entrance. We propose a mechanism of CaM-mediated Ca2+-induced inactivation that can be explored for therapeutic design."xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aau6088"xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/author | "Singh A.K."xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/author | "Twomey E.C."xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/author | "Sobolevsky A.I."xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/author | "McGoldrick L.L."xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/pages | "eaau6088"xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/title | "Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6."xsd:string |
| http://purl.uniprot.org/citations/30116787 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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