| http://purl.uniprot.org/citations/30122475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30122475 | http://www.w3.org/2000/01/rdf-schema#comment | "Mbd3, a member of nucleosome remodeling and deacetylase (NuRD) co-repressor complex, was previously identified as an inhibitor for deterministic induced pluripotent stem cell (iPSC) reprogramming, where up to 100% of donor cells successfully complete the process. NuRD can assume multiple mutually exclusive conformations, and it remains unclear whether this deterministic phenotype can be attributed to a specific Mbd3/NuRD subcomplex. Moreover, since complete ablation of Mbd3 blocks somatic cell proliferation, we aimed to explore functionally relevant alternative ways to neutralize Mbd3-dependent NuRD activity. We identify Gatad2a, a NuRD-specific subunit, whose complete deletion specifically disrupts Mbd3/NuRD repressive activity on the pluripotency circuitry during iPSC differentiation and reprogramming without ablating somatic cell proliferation. Inhibition of Gatad2a facilitates deterministic murine iPSC reprogramming within 8 days. We validate a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2018.07.004"xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Levin Y."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Hanna S."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Mor N."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Elling U."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Hagai T."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Bergman Y."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Esteban M.A."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Greenleaf W.J."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Aguilera-Castrejon A."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Bayerl J."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Chomsky E."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Geula S."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Hanna J.H."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Krupalnik V."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Lasman L."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Massarwa R."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Novershtern N."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Peles S."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Rais Y."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Shani T."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Viukov S."xsd:string |
| http://purl.uniprot.org/citations/30122475 | http://purl.uniprot.org/core/author | "Zerbib M."xsd:string |