| http://purl.uniprot.org/citations/30122535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30122535 | http://www.w3.org/2000/01/rdf-schema#comment | "NusG/Spt5 proteins are the only transcription factors utilized by all cellular organisms. In enterobacteria, NusG antagonizes the transcription termination activity of Rho, a hexameric helicase, during the synthesis of ribosomal and actively translated mRNAs. Paradoxically, NusG helps Rho act on untranslated transcripts, including non-canonical antisense RNAs and those arising from translational stress; how NusG fulfills these disparate functions is unknown. Here, we demonstrate that NusG activates Rho by assisting helicase isomerization from an open-ring, RNA-loading state to a closed-ring, catalytically active translocase. A crystal structure of closed-ring Rho in complex with NusG reveals the physical basis for this activation and further explains how Rho is excluded from translationally competent RNAs. This study demonstrates how a universally conserved transcription factor acts to modulate the activity of a ring-shaped ATPase motor and establishes how the innate sequence bias of a termination factor can be modulated to silence pervasive, aberrant transcription."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2018.07.014"xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Berger J.M."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Martin A."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Schulten K."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Artsimovitch I."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Landick R."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Lawson M.R."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/author | "Bellecourt M.J."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/pages | "911-922.e4"xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/title | "Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein."xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/30122535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30122535 |
| http://purl.uniprot.org/citations/30122535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30122535 |
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| http://purl.uniprot.org/uniprot/#_P0AG30-mappedCitation-30122535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30122535 |
| http://purl.uniprot.org/uniprot/P0AFG0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30122535 |
| http://purl.uniprot.org/uniprot/P0AG30 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30122535 |