| http://purl.uniprot.org/citations/30139745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30139745 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Myc is a proto-oncogene controlling expression of multiple genes involved in cell growth and differentiation. Although the functional role of c-Myc as a transcriptional regulator has been intensively studied, targeting this protein in cancer remains a challenge. Here, we report a trimodal regulation of c-Myc function by the Ras effector, Ras-association domain family member 7 (RASSF7), a nonenzymatic protein modulating protein-protein interactions to regulate cell proliferation. Using HEK293T and HeLa cell lines, we provide evidence that RASSF7 destabilizes the c-Myc protein by promoting Cullin4B-mediated polyubiquitination and degradation. Furthermore, RASSF7 competed with MYC-associated factor X (MAX) in the formation of a heterodimeric complex with c-Myc and attenuated its occupancy on target gene promoters to regulate transcription. Consequently, RASSF7 inhibited c-Myc-mediated oncogenic transformation, and an inverse correlation between the expression levels of the RASSF7 and c-Myc genes was evident in human cancers. Furthermore, we found that RASSF7 interacts with c-Myc via its RA and leucine zipper (LZ) domains and LZ domain peptide is sufficient to inhibit c-Myc function, suggesting that this peptide might be used to target oncogenic c-Myc. These results unveil that RASSF7 and c-Myc are functionally linked in the control of tumorigenesis and open up potential therapeutic avenues for targeting the "undruggable" c-Myc protein in a subset of human cancers."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra118.004452"xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Desai P."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Ramakrishnan C."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Mahalingam S."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Rajalingam K."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Mamidi A."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Perumalsamy L.R."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Kumaraswamy A."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Gromiha M."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/author | "Sivagnanam A."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/pages | "15691-15705"xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/title | "The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc function."xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/30139745 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30139745 |
| http://purl.uniprot.org/citations/30139745 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30139745 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-30139745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30139745 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-30139745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30139745 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-30139745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30139745 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-30139745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30139745 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-30139745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30139745 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-30139745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30139745 |