| http://purl.uniprot.org/citations/30156010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30156010 | http://www.w3.org/2000/01/rdf-schema#comment | "The deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with a high risk of mesothelioma and melanocytic tumors. Here, we show that Bap1 deletion in melanocytes cooperates with the constitutively active, oncogenic form of BRAF (BRAFV600E ) and UV to cause melanoma in mice, albeit at very low frequency. In addition, Bap1-null melanoma cells derived from mouse tumors are more aggressive and colonize and grow at distant sites more than their wild-type counterparts. Molecularly, Bap1-null melanoma cell lines have increased DNA damage measured by γH2aX and hyperubiquitination of histone H2a. Therapeutically, these Bap1-null tumors are completely responsive to BRAF- and MEK-targeted therapies. Therefore, BAP1 functions as a tumor suppressor and limits tumor progression in melanoma."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.org/dc/terms/identifier | "doi:10.1111/pcmr.12735"xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Chan S."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Sharma N."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Dey A."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Modrusan Z."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Chaurushiya M.S."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Pham T.H."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Hung J."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Lee W.P."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Chang M.T."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Bastian B.C."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Webster J.D."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Chalasani S."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Tran C."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Totpal K."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Hotzel K."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Stawiski E.W."xsd:string |
| http://purl.uniprot.org/citations/30156010 | http://purl.uniprot.org/core/author | "Lill J."xsd:string |