| http://purl.uniprot.org/citations/30158529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30158529 | http://www.w3.org/2000/01/rdf-schema#comment | "Although many factors contribute to cellular differentiation, the role of mitochondria Ca2+ dynamics during development remains unexplored. Because mammalian embryonic epiblasts reside in a hypoxic environment, we intended to understand whether mCa2+ and its transport machineries are regulated during hypoxia. Tissues from multiple organs of developing mouse embryo evidenced a suppression of MICU1 expression with nominal changes on other MCU complex components. As surrogate models, we here utilized human embryonic stem cells (hESCs)/induced pluripotent stem cells (hiPSCs) and primary neonatal myocytes to delineate the mechanisms that control mCa2+ and bioenergetics during development. Analysis of MICU1 expression in hESCs/hiPSCs showed low abundance of MICU1 due to its direct repression by Foxd1. Experimentally, restoration of MICU1 established the periodic cCa2+ oscillations and promoted cellular differentiation and maturation. These findings establish a role of mCa2+ dynamics in regulation of cellular differentiation and reveal a molecular mechanism underlying this contribution through differential regulation of MICU1."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-05856-4"xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Dong Z."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Rajan S."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Madesh M."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Ibetti J."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Nemani N."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Shanmughapriya S."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Tomar D."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Carvalho E."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Barrero C."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Merali S."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Natarajaseenivasan K."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Kishore R."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Slovik K.J."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Chuprun K."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Garikipati V.N.S."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/author | "Corrigan K."xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30158529 | http://purl.uniprot.org/core/pages | "3449"xsd:string |