| http://purl.uniprot.org/citations/30166349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30166349 | http://www.w3.org/2000/01/rdf-schema#comment | "Animals utilize conserved mechanisms to regulate oxidative stress. The C. elegans SKN-1 protein is homologous to the vertebrate Nrf (NF-E2-related factor) family of cap 'n' collar (CnC) transcription factors and functions as a core regulator of xenobiotic and oxidative stress responses. The WD40 repeat-containing protein WDR-23 is a key negative regulator of SKN-1 activity. We previously found that the oxidative stress induced by excess iodide can be relieved by loss of function in the BLI-3/TSP-15/DOXA-1 dual oxidase complex. To further understand the molecular mechanism of this process, we screened for new mutants that can survive in excess iodide and identified gain-of-function mutations in skn-1 and loss-of-function mutations in wdr-23 The SKN-1C isoform functions in the hypodermis to affect animal's response to excess iodide, while the SKN-1A isoform appears to play a minor role. wdr-23(lf) can interact with bli-3 mutations in a manner different from skn-1(gf) Transcriptome studies suggest that excess iodide causes developmental arrest largely independent of changes in gene expression, and wdr-23(lf) could affect the expression of a subset of genes by a mechanism different from SKN-1 activation. We propose that WDR-23 and SKN-1 coordinate with the BLI-3/TSP-15/DOXA-1 dual oxidase complex in response to iodide-triggered oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.118.200586"xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Hua H."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Pan Q."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Ma D.K."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/author | "Nie Q."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/pages | "3515-3527"xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/title | "WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress."xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30166349 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30166349 |
| http://purl.uniprot.org/citations/30166349 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30166349 |
| http://purl.uniprot.org/uniprot/#_P34298-mappedCitation-30166349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30166349 |
| http://purl.uniprot.org/uniprot/#_P34707-mappedCitation-30166349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30166349 |
| http://purl.uniprot.org/uniprot/#_C6KRL4-mappedCitation-30166349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30166349 |
| http://purl.uniprot.org/uniprot/#_P90794-mappedCitation-30166349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30166349 |
| http://purl.uniprot.org/uniprot/#_O61213-mappedCitation-30166349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30166349 |