| http://purl.uniprot.org/citations/30166592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30166592 | http://www.w3.org/2000/01/rdf-schema#comment | "Platinum drugs are used in first-line to treat ovarian cancer, but most of the patients eventually generate resistance after treatment with these drugs. Although both c-Myc and EZH2 have been implicated in regulating cisplatin resistance in ovarian cancer, the interplay between these two regulators is poorly understood. Using RNA sequence analysis (RNA-seq), for the first time we find that miR-137 level is extremely low in cisplatin resistant ovarian cancer cells, correlating with higher levels of c-Myc and EZH2 expression. Further analyses indicate that in resistant cells c-Myc enhances the expression of EZH2 by directly suppressing miR-137 that targets EZH2 mRNA, and increased expression of EZH2 activates cellular survival pathways, resulting in the resistance to cisplatin. Inhibition of c-Myc-miR-137-EZH2 pathway re-sensitizes resistant cells to cisplatin. Both in vivo and in vitro analyses indicate that cisplatin treatment activates c-Myc-miR-137-EZH2 pathway. Importantly, elevated c-Myc-miR-137-EZH2 pathway in resistant cells is sustained by dual oxidase maturation factor 1 (DUOXA1)-mediated production of reactive oxygen species (ROS). Significantly, clinical studies further confirm the activated c-Myc-miR-137-EZH2 pathway in platinum drug-resistant or recurrent ovarian cancer patients. Thus, our studies elucidate a novel role of miR-137 in regulating c-Myc-EZH2 axis that is crucial to the regulation of cisplatin resistance in ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41388-018-0459-x"xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Cai X."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Peng W."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Kai Y."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Dai Z."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Chan D.W."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Liu S.S."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Yung M.M."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Ngan H.Y.S."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Tzatsos A."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/author | "Cheung A.N.Y."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/pages | "564-580"xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/title | "miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/30166592 | http://purl.uniprot.org/core/volume | "38"xsd:string |