| http://purl.uniprot.org/citations/30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30169732 | http://www.w3.org/2000/01/rdf-schema#comment | "Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxy025"xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/author | "Miki H."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/author | "Hitomi K."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/author | "Iwata K."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/author | "Tahara-Hanaoka S."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/author | "Shibayama S."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/pages | "429-434"xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/title | "Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice."xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/30169732 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30169732 |
| http://purl.uniprot.org/citations/30169732 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30169732 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1N6-mappedCitation-30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30169732 |
| http://purl.uniprot.org/uniprot/#_A0A140T8Q6-mappedCitation-30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30169732 |
| http://purl.uniprot.org/uniprot/#_A4ZVL1-mappedCitation-30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30169732 |
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| http://purl.uniprot.org/uniprot/#_P05532-mappedCitation-30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30169732 |
| http://purl.uniprot.org/uniprot/#_Q3TB92-mappedCitation-30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30169732 |
| http://purl.uniprot.org/uniprot/#_Q3ULJ6-mappedCitation-30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30169732 |
| http://purl.uniprot.org/uniprot/#_S4R1V2-mappedCitation-30169732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30169732 |