| http://purl.uniprot.org/citations/30173119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30173119 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-33, a member of the IL-1 cytokine family, is highly expressed in central nervous system (CNS), suggesting its potential role in CNS. Although some studies have focused on the role of IL-33 in multiple sclerosis (MS) / experimental autoimmune encephalomyelitis (EAE), an autoimmune disease characterized by demyelination and axonal damage in CNS, the exact role of IL-33 in MS/EAE remains unclear and controversial. Here, we used IL-33 knockout mice to clarify the role of endogenous IL-33 in EAE by simultaneously eliminating its role as a nuclear transcription factor and an extracellular cytokine. We found that the clinical score in IL-33 knockout EAE mice was higher accompanied by more severe demyelination compared with the wild-type (WT) EAE mice. As for the main immune cells participating in EAE in IL-33 knockout mice, pathogenic effector T cells increased both in peripheral immune organs and CNS, while CD4+FOXP3+ regulatory T cells decreased in spleen and lymph nodes, Th2 cells and natural killer (NK) cells decreased in CNS. Additionally, the populations of microglia/macrophages and CD11C+CD11B+ dendritic cells (DCs) increased in CNS of IL-33 knockout mice with EAE, among which iNOS-producing microglia/macrophages increased. Moreover, resident astrocytes/microglia were more activated in IL-33 knockout mice with EAE. In vitro, after blocking the IL-33, the proliferation of primary astrocytes, the production of MCP-1/CCL2 and TNF-α by astrocytes, and the production of TNF-α by primary microglia stimulated by the homogenate of the peak stage of EAE were increased. Our results indicate that IL-33 plays a protective role in EAE and exerts extensive influences on multiple immune cells and neural cells involved in EAE."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2018.08.026"xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Gong F."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Wu N."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Zheng F."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Mao J."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Zeng F."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Lai L."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/author | "Tan Z."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/pages | "550-563"xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/title | "Interleukin-33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells."xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/30173119 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30173119 |
| http://purl.uniprot.org/citations/30173119 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30173119 |
| http://purl.uniprot.org/uniprot/#_A0A1I9RI50-mappedCitation-30173119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30173119 |