| http://purl.uniprot.org/citations/30177872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30177872 | http://www.w3.org/2000/01/rdf-schema#comment | "Light is the main environmental stimulus that synchronizes the endogenous timekeeping systems in most terrestrial organisms. Drosophila cryptochrome (dCRY) is a light-responsive flavoprotein that detects changes in light intensity and wavelength around dawn and dusk. We have previously shown that dCRY acts through Inactivation No Afterpotential D (INAD) in a light-dependent manner on the Signalplex, a multiprotein complex that includes visual-signaling molecules, suggesting a role for dCRY in fly vision. Here, we predict and demonstrate a novel Ca2+-dependent interaction between dCRY and calmodulin (CaM). Through yeast two hybrid, coimmunoprecipitation (Co-IP), nuclear magnetic resonance (NMR) and calorimetric analyses we were able to identify and characterize a CaM binding motif in the dCRY C-terminus. Similarly, we also detailed the CaM binding site of the scaffold protein INAD and demonstrated that CaM bridges dCRY and INAD to form a ternary complex in vivo. Our results suggest a process whereby a rapid dCRY light response stimulates an interaction with INAD, which can be further consolidated by a novel mechanism regulated by CaM."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.org/dc/terms/identifier | "doi:10.3389/fnmol.2018.00280"xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Minervini G."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Stefani M."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Tosatto S.C.E."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Costa R."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Mammi S."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Bellanda M."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Zambelli B."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Cusumano P."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Aufiero S."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Damulewicz M."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/author | "Mazzotta G.M."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/name | "Front Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/pages | "280"xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/title | "Calmodulin Enhances Cryptochrome Binding to INAD in Drosophila Photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/30177872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30177872 |
| http://purl.uniprot.org/citations/30177872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30177872 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF57-mappedCitation-30177872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30177872 |
| http://purl.uniprot.org/uniprot/#_D3DMF9-mappedCitation-30177872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30177872 |
| http://purl.uniprot.org/uniprot/#_Q24008-mappedCitation-30177872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30177872 |
| http://purl.uniprot.org/uniprot/#_O77059-mappedCitation-30177872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30177872 |