| http://purl.uniprot.org/citations/30181179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30181179 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC). Hepatic macrophages play a critical role in the inflammatory process leading to HCC. The oncogene Astrocyte elevated gene-1 (AEG-1) regulates NFκB activation, and germline knockout of AEG-1 in mice (AEG-1-/-) results in resistance to inflammation and experimental HCC. In this study, we developed conditional hepatocyte- and myeloid cell-specific AEG-1-/- mice (AEG-1ΔHEP and AEG-1ΔMAC, respectively) and induced HCC by treatment with N-nitrosodiethylamine (DEN) and phenobarbital (PB). AEG-1ΔHEP mice exhibited a significant reduction in disease severity compared with control littermates, while AEG-1ΔMAC mice were profoundly resistant. In vitro, AEG-1-/- hepatocytes exhibited increased sensitivity to stress and senescence. Notably, AEG-1-/- macrophages were resistant to either M1 or M2 differentiation with significant inhibition in migration, endothelial adhesion, and efferocytosis activity, indicating that AEG-1 ablation renders macrophages functionally anergic. These results unravel a central role of AEG-1 in regulating macrophage activation and indicate that AEG-1 is required in both tumor cells and tumor microenvironment to stimulate hepatocarcinogenesis.Significance: These findings distinguish a novel role of macrophage-derived oncogene AEG-1 from hepatocellular AEG-1 in promoting inflammation and driving tumorigenesis. Cancer Res; 78(22); 6436-46. ©2018 AACR."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-18-0659"xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Lai Z."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Dozmorov M."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Windle J.J."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Subler M.A."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Robertson C.L."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Mukhopadhyay N.D."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Jariwala N."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/author | "Mendoza R.G."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/pages | "6436-6446"xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/title | "Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/30181179 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30181179 |
| http://purl.uniprot.org/citations/30181179 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30181179 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-30181179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30181179 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRF4-mappedCitation-30181179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30181179 |
| http://purl.uniprot.org/uniprot/#_E9PUX0-mappedCitation-30181179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30181179 |
| http://purl.uniprot.org/uniprot/#_F6QFT1-mappedCitation-30181179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30181179 |