| http://purl.uniprot.org/citations/30181240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30181240 | http://www.w3.org/2000/01/rdf-schema#comment | "Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain-like (MLKL) translocated from the cytoplasm to the plasma membrane and stimulated downstream NADPH oxidase-independent ROS production, loss of cytoplasmic granules, breakdown of the nuclear membrane, chromatin decondensation, histone hypercitrullination, and extrusion of bacteriostatic NETs. This process was coordinated by receptor-interacting protein kinase-1 (RIPK1), which activated the caspase-8-dependent apoptotic or RIPK3/MLKL-dependent necroptotic death of mouse and human neutrophils. Genetic deficiency of RIPK3 and MLKL prevented NET formation but did not prevent cell death, which was because of residual caspase-8-dependent activity. Peptidylarginine deiminase 4 (PAD4) was activated downstream of RIPK1/RIPK3/MLKL and was required for maximal histone hypercitrullination and NET extrusion. This work defines a distinct signaling network that activates PAD4-dependent NET release for the control of methicillin-resistant Staphylococcus aureus (MRSA) infection."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.aao1716"xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Ericsson M."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Williams D.A."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Vince J.E."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Croker B.A."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Lawlor K.E."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Kelliher M.A."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Pasparakis M."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Hakem R."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "D'Cruz A.A."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Dietrich S."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Speir M."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Chen A.A."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Bliss-Moreau M."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Gavillet M."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/author | "Al-Obeidi A."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/pages | "eaao1716"xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/title | "The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils."xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/30181240 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30181240 |