| http://purl.uniprot.org/citations/30183071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30183071 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular pattern recognition receptors (PRRs) that regulate a variety of inflammatory and host defense responses. Unlike the well-established NLRs, the roles of NLRP2 are controversial and poorly defined. Here, we report that NLRP2 acts as a negative regulator of TANK-binding kinase 1 (TBK1)-mediated type I interferon (IFN) signaling. Mechanistically, NLRP2 interacted directly with TBK1, and this binding disrupted the interaction of TBK1 and interferon regulatory factor 3 (IRF3), which interfered with TBK1-induced IRF3 phosphorylation. IFNs induce a series of proteins that have well-known antiviral or immune-regulatory functions, and tight control of the IFN signaling cascade is critical for limiting tissue damage and preventing autoimmunity. Our studies indicate that the NLRP2-TBK1 axis may serve as an additional signaling cascade to maintain immune homeostasis in response to viral infection."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201847589"xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Hu J."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Sun S."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Ding S."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Gong T."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/author | "Lang X."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/pages | "1817-1825"xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/title | "NLRP2 negatively regulates antiviral immunity by interacting with TBK1."xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/30183071 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30183071 |
| http://purl.uniprot.org/citations/30183071 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30183071 |
| http://purl.uniprot.org/uniprot/#_A8K9G6-mappedCitation-30183071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30183071 |
| http://purl.uniprot.org/uniprot/#_B4E164-mappedCitation-30183071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30183071 |
| http://purl.uniprot.org/uniprot/#_J3KN39-mappedCitation-30183071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30183071 |
| http://purl.uniprot.org/uniprot/#_Q9UHD2-mappedCitation-30183071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30183071 |
| http://purl.uniprot.org/uniprot/#_Q8WY49-mappedCitation-30183071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30183071 |