| http://purl.uniprot.org/citations/30183325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30183325 | http://www.w3.org/2000/01/rdf-schema#comment | "IFN-λ and IL-22, cytokines that share the coreceptor IL-10RB, are both induced over the course of Klebsiella pneumoniae ST258 (KP35) pneumonia. IL-22 is known to protect mucosal barriers, whereas the effects of IFN-λ on the mucosa are not established. We postulated that IFN-λ plays a role in regulating the airway epithelial barrier to facilitate cellular trafficking to the site of infection. In response to IFN-λ, the transmigration of neutrophils across a polarized monolayer of airway epithelial cells was increased, consistent with diminished epithelial integrity. KP35 infection increased epithelial permeability, and pretreatment with IFN-λ amplified this effect and facilitated bacterial transmigration. These effects of IFN-λ were confirmed in vivo, in that mice lacking the receptor for IFN-λ (Ifnlr1-/-) were protected from bacteremia in a murine model of KP35 pneumonia. Conversely, the integrity of the epithelial barrier was protected by IL-22, with subsequent impairment of neutrophil and bacterial transmigration in vitro. Maximal expression of IL-22 in vivo was observed later in the course of infection than IFN-λ production, with high levels of IL-22 produced by recruited immune cells at 48 hours, consistent with a role in epithelial barrier recovery. The divergent and opposing expression of these two related cytokines suggests a regulated interaction in the host response to KP35 infection. A major physiological effect of IFN-λ signaling is a decrease in epithelial barrier integrity, which facilitates immune cell recruitment but also enables K. pneumoniae invasion."xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2018-0021oc"xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/author | "Prince A."xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/author | "Ahn D."xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/author | "Riquelme S."xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/author | "Wickersham M."xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/pages | "158-166"xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/title | "The Effects of IFN-lambda on Epithelial Barrier Function Contribute to Klebsiella pneumoniae ST258 Pneumonia."xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/30183325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30183325 |
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