| http://purl.uniprot.org/citations/30185805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30185805 | http://www.w3.org/2000/01/rdf-schema#comment | "The inheritance of gene expression patterns is dependent on epigenetic regulation, but the establishment and maintenance of epigenetic landscapes during T cell differentiation are incompletely understood. Here we show that two stage-specific Cd4 cis-elements, the previously characterized enhancer E4p and a novel enhancer E4m, coordinately promote Cd4 transcription in mature thymic MHC-II-specific T cells, in part through the canonical Wnt pathway. Specifically, E4p licenses E4m to orchestrate DNA demethylation by TET1 and TET3, which in turn poises the Cd4 locus for transcription in peripheral T cells. Cd4 locus demethylation is important for subsequent Cd4 transcription in activated peripheral T cells wherein these cis-elements become dispensable. By contrast, in developing thymocytes the loss of TET1/3 does not affect Cd4 transcription, highlighting an uncoupled event between transcription and epigenetic modifications. Together our findings reveal an important function for thymic cis-elements in governing gene expression in the periphery via a heritable epigenetic mechanism."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-05834-w"xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Myers R.M."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Au C."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Littman D.R."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Xue H.H."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Skok J.A."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Day K."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Zappile P."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Issuree P.D."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/author | "Raviram R."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/pages | "3594"xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/title | "Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development."xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30185805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30185805 |
| http://purl.uniprot.org/citations/30185805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30185805 |
| http://purl.uniprot.org/uniprot/#_A0A087WP90-mappedCitation-30185805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30185805 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MAW8-mappedCitation-30185805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30185805 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MHT7-mappedCitation-30185805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30185805 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MHU2-mappedCitation-30185805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30185805 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MGW8-mappedCitation-30185805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30185805 |
| http://purl.uniprot.org/uniprot/#_E0CYR1-mappedCitation-30185805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30185805 |