http://purl.uniprot.org/citations/30187366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/30187366 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundNarcolepsy is an uncommon neurological disorder characterised by irresistible spells of sleep associated with abnormal rapid eye movement (REM) sleep. The association between narcolepsy and human leukocyte antigen HLA-DQB1*06:02 has been established elsewhere but remains to be investigated among Saudi Arabian patients with narcolepsy.MethodsA total of 29 Saudi patients with type I or type 2 narcolepsy comprising of 23 (79%) males and 6 (21%) females with a mean age of 17.2 ± 9.6 years were included in this study. Type 1 or type 2 narcolepsy was diagnosed by full polysomnography followed by a multiple sleep latency test in accordance with International Classifications of Sleep Disorders-3 criteria. HLA typing for DQB1 alleles was performed by polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes. Differences in clinical and sleep parameters were compared by univariable analyses. HLA-DQB1*06:02 frequency was systematically compared with the published literature.ResultsType 1 narcolepsy was diagnosed in 19/29 (65.5%) patients, whereas 10/29 (34.5%) patients had type 2 narcolepsy. DQB1*06:02 was present in 25/29 (86.2%) patients; 15/19 (78.9%) narcolepsy type 1 patients and 10/10 (100%) narcolepsy type 2 patients harboured the DQB1*06:02 allele. REM latency was significantly lower in DQB1*06:02-positive patients compared to DQB1*06:02-negative patients (17.6 ± 32.3 min vs. 106.0 ± 86.0 min; p = 0.025). Epworth Sleepiness Scale scores were significantly higher among type 1 than type 2 narcolepsy patients (19.7 ± 3.2 vs 15.3 ± 3.6; p = 0.02).ConclusionsDQB1*06:02 allele frequencies among Saudi patients with narcolepsy were consistent with previously published data."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11325-018-1717-4"xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "BaHammam A.S."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "Hamam K.D."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "Shakoor Z."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "Alharbi A.S."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "Al Shareef S.M."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "AlAnbay E."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "AlKhathlan M.A."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "Almeneessier A.S."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/author | "Alnasser M."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/name | "Sleep Breath"xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/pages | "303-309"xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/title | "HLA-DQB1*06:02 allele frequency and clinic-polysomnographic features in Saudi Arabian patients with narcolepsy."xsd:string |
http://purl.uniprot.org/citations/30187366 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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