DESCRIBE <http://purl.uniprot.org/citations/30188892>

Subject	Predicate	Object
http://purl.uniprot.org/citations/30188892	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30188892	http://www.w3.org/2000/01/rdf-schema#comment	"FGF signaling is a potent inducer of lacrimal gland development in the eye, capable of transforming the corneal epithelium into glandular tissues. Here, we show that genetic ablation of the Pea3 family of transcription factors not only disrupted the ductal elongation and branching of the lacrimal gland, but also biased the lacrimal gland epithelium toward an epidermal cell fate. Analysis of high-throughput gene expression and chromatin immunoprecipitation data revealed that the Pea3 genes directly control both the positive and negative feedback loops of FGF signaling. Importantly, Pea3 genes are also required to suppress aberrant Notch signaling which, if gone unchecked, can compromise lacrimal gland development by preventing the expression of both Sox and Six family genes. These results demonstrate that Pea3 genes are key FGF early response transcriptional factors, programing the genetic landscape for cell fate determination."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.org/dc/terms/identifier	"doi:10.1371/journal.pgen.1007660"xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Bansal M."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Zhang X."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Wang Q."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Zhong J."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Xu K."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Garg A."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Teng S."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Collins T."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/author	"Hannan A."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/date	"2018"xsd:gYear
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/name	"PLoS Genet"xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/pages	"e1007660"xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/title	"FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination."xsd:string
http://purl.uniprot.org/citations/30188892	http://purl.uniprot.org/core/volume	"14"xsd:string
http://purl.uniprot.org/citations/30188892	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/30188892
http://purl.uniprot.org/citations/30188892	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/30188892
http://purl.uniprot.org/uniprot/#_D3Z5M8-mappedCitation-30188892	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30188892
http://purl.uniprot.org/uniprot/#_E0CXX3-mappedCitation-30188892	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30188892
http://purl.uniprot.org/uniprot/#_E0CYI1-mappedCitation-30188892	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30188892
http://purl.uniprot.org/uniprot/#_E0CYN8-mappedCitation-30188892	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30188892
http://purl.uniprot.org/uniprot/#_E0CZ37-mappedCitation-30188892	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30188892
http://purl.uniprot.org/uniprot/#_E0CZ54-mappedCitation-30188892	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/30188892