| http://purl.uniprot.org/citations/3018929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3018929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3018929 | http://www.w3.org/2000/01/rdf-schema#comment | "Biological and serological assays have been used to define four subregions for the I region of the major histocompatibility complex (MHC) in the order I-A, I-B, I-J, and I-E. The I-J subregion presumably encodes the I-J polypeptide of the elusive T-cell suppressor factors. Restriction enzyme site polymorphisms and DNA sequence analyses of the I region from four recombinant mouse strains were used to localize the putative I-B and I-J subregions to a 1.0-kilobase (kb) region within the E beta gene. Sequencing this region from E beta clones derived from the two mouse strains: B10.A(3R), I-Jb and B10.A(5R), I-Jk initially used to define the I-J subregion revealed that these regions are identical, hence the distinct I-Jb and I-Jk molecules cannot be encoded by this DNA. In addition, the DNA sequence data also refute the earlier mapping of the I-B subregion. Analysis of the DNA sequences of three parental and four I region recombinants reveals that the recombinant events in three of the recombinant strains occurred within a 1-kb region of DNA, supporting the proposition that a hotspot for recombination exists in the I region. The only striking feature of this hotspot is a tetramer repeat (AGGC)n that shows 80 percent homology to the minisatellite sequence which may facilitate recombination in human chromosomes."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.3018929"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.3018929"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Hood L."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Hood L."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Strauss E."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Strauss E."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Kobori J.A."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Kobori J.A."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Minard K."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/author | "Minard K."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/pages | "173-179"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/pages | "173-179"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/title | "Molecular analysis of the hotspot of recombination in the murine major histocompatibility complex."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/title | "Molecular analysis of the hotspot of recombination in the murine major histocompatibility complex."xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/volume | "234"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://purl.uniprot.org/core/volume | "234"xsd:string |
| http://purl.uniprot.org/citations/3018929 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3018929 |
| http://purl.uniprot.org/citations/3018929 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/3018929 |