| http://purl.uniprot.org/citations/30192230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30192230 | http://www.w3.org/2000/01/rdf-schema#comment | "The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumors, and an aggressive Natural Killer cell-like leukemia for which no animal model has been developed. Because the tp53 deletion was generated in syngeneic zebrafish, engraftment of fluorescent-labeled tumors could be dynamically visualized over time. Importantly, engrafted tumors shared gene expression signatures with predicted cells of origin in human tissue. Finally, we showed that tp53del/del enhanced invasion and metastasis in kRASG12D-induced embryonal rhabdomyosarcoma (ERMS), but did not alter the overall frequency of cancer stem cells, suggesting novel pro-metastatic roles for TP53 loss-of-function in human muscle tumors. In summary, we have developed a Li-Fraumeni zebrafish model that is amenable to large-scale transplantation and direct visualization of tumor growth in live animals."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.37202"xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Tang Q."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Chen E.Y."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Blackburn P.R."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Baxi K."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Jin A."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Langenau D.M."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Tirode F."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Ekker S.C."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Ramakrishnan A."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Hasserjian R.P."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Moore F.E."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Ignatius M.S."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Garcia S.P."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Hayes M.N."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Nielsen G.P."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/author | "Reeder S."xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/pages | "e37202"xsd:string |
| http://purl.uniprot.org/citations/30192230 | http://purl.uniprot.org/core/title | "tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish."xsd:string |