| http://purl.uniprot.org/citations/30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30194290 | http://www.w3.org/2000/01/rdf-schema#comment | "In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the specific protein interactomes of each RAS isoform by BirA proximity-dependent biotin identification. The combined interactomes are screened by CRISPR-Cas9 loss-of-function assays for proteins required for oncogenic KRAS-dependent, NRAS-dependent, or HRAS-dependent proliferation and censored for druggable proteins. Using this strategy, we identify phosphatidylinositol phosphate kinase PIP5K1A as a KRAS-specific interactor and show that PIP5K1A binds to a unique region in KRAS. Furthermore, PIP5K1A depletion specifically reduces oncogenic KRAS signaling and proliferation, and sensitizes pancreatic cancer cell lines to a MAPK inhibitor. These results suggest PIP5K1A as a potential target in KRAS signaling for the treatment of KRAS-mutant cancers."xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-05692-6"xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://purl.uniprot.org/core/author | "Counter C.M."xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://purl.uniprot.org/core/author | "Adhikari H."xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30194290 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://purl.uniprot.org/core/pages | "3646"xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://purl.uniprot.org/core/title | "Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability."xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30194290 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30194290 |
| http://purl.uniprot.org/citations/30194290 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30194290 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ1-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A0A5P8I3H7-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ4-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A0A221ZRZ5-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A5HC25-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_B4DY52-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A5HC02-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A5HC19-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A5HC23-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_A6PW57-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_P01116-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_E5FF39-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |
| http://purl.uniprot.org/uniprot/#_L7RSL8-mappedCitation-30194290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194290 |