| http://purl.uniprot.org/citations/30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30194291 | http://www.w3.org/2000/01/rdf-schema#comment | "Haploinsufficiency and aneuploidy are two phenomena, where gene dosage alterations cause severe defects ultimately resulting in developmental failures and disease. One remarkable exception is the X chromosome, where copy number differences between sexes are buffered by dosage compensation systems. In Drosophila, the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. The evolutionary origin and conservation of this process orchestrated by MSL2, the only male-specific protein within the fly MSLc, have remained unclear. Here, we report that MSL2, in addition to regulating the X chromosome, targets autosomal genes involved in patterning and morphogenesis. Precise regulation of these genes by MSL2 is required for proper development. This set of dosage-sensitive genes maintains such regulation during evolution, as MSL2 binds and similarly regulates mouse orthologues via Histone H4 lysine 16 acetylation. We propose that this gene-by-gene dosage compensation mechanism was co-opted during evolution for chromosome-wide regulation of the Drosophila male X."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-05642-2"xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/author | "Akhtar A."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/author | "Semplicio G."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/author | "Georgiev P."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/author | "Basilicata M.F."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/author | "Valsecchi C.I.K."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/author | "Gutierrez N.M."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/pages | "3626"xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/title | "Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30194291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30194291 |
| http://purl.uniprot.org/citations/30194291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30194291 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFI7-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEK5-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_E1JGX9-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_E1JGY0-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K883-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KED7-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7L1-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_A4V038-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EF55-mappedCitation-30194291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30194291 |