| http://purl.uniprot.org/citations/30194420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30194420 | http://www.w3.org/2000/01/rdf-schema#comment | "Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto the surface of cognate antigen-bearing APCs. Microvilli carry T cell receptors (TCR) at all stages of T cell activation and are released as large TCR-enriched, T cell microvilli particles (TMP) in a process of trogocytosis. These microvilli exclusively contain protein arrestin-domain-containing protein 1, which is directly involved in membrane budding and, in combination with vacuolar protein-sorting-associated protein 4, transforms large TMPs into smaller, exosome-sized TMPs. Notably, TMPs from CD4+ T cells are enriched with LFA-2/CD2 and various cytokines involved in activating dendritic cells. Collectively, these results demonstrate that T cell microvilli constitute "immunological synaptosomes" that carry T cell messages to APCs."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06090-8"xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Kim C.H."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Park C.S."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Park Y.J."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Kim H.R."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Lee S.M."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Jun Y."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Im S.H."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Jeon B.N."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Jun C.D."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Hyun Y.M."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/author | "Mun Y."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/pages | "3630"xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/title | "T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells."xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/30194420 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30194420 |
| http://purl.uniprot.org/citations/30194420 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30194420 |