| http://purl.uniprot.org/citations/30213859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30213859 | http://www.w3.org/2000/01/rdf-schema#comment | "In many eukaryotes, translation initiation is regulated by proteins that bind to the mRNA cap-binding protein eukaryotic translation initiation factor 4E (eIF4E). These proteins commonly prevent association of eIF4E with eIF4G or form repressive messenger ribonucleoproteins that exclude the translation machinery. Such gene-regulatory mechanisms in plants, and even the presence of eIF4E-interacting proteins other than eIF4G (and the plant-specific isoform eIFiso4G, which binds eIFiso4E), are unknown. Here, we report the discovery of a plant-specific protein, conserved binding of eIF4E 1 (CBE1). We found that CBE1 has an evolutionarily conserved eIF4E-binding motif in its N-terminal domain and binds eIF4E or eIFiso4E in vitro CBE1 thereby forms cap-binding complexes and is an eIF4E-dependent constituent of these complexes in vivo Of note, plant mutants lacking CBE1 exhibited dysregulation of cell cycle-related transcripts and accumulated higher levels of mRNAs encoding proteins involved in mitosis than did WT plants. Our findings indicate that CBE1 is a plant protein that can form mRNA cap-binding complexes having the potential for regulating gene expression. Because mammalian translation factors are known regulators of cell cycle progression, we propose that CBE1 may represent such first translation factor-associated plant-specific cell cycle regulator."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra118.003945"xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/author | "Yang S.H."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/author | "Browning K.S."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/author | "Patrick R.M."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/author | "Choy G.S."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/author | "Lee J.C.H."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/author | "Teetsel J.R.J."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/pages | "17240-17247"xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/title | "Discovery and characterization of conserved binding of eIF4E 1 (CBE1), a eukaryotic translation initiation factor 4E-binding plant protein."xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/30213859 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30213859 |
| http://purl.uniprot.org/citations/30213859 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30213859 |
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| http://purl.uniprot.org/uniprot/#_O23252-mappedCitation-30213859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30213859 |
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| http://purl.uniprot.org/uniprot/#_Q54A13-mappedCitation-30213859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30213859 |