| http://purl.uniprot.org/citations/30228226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30228226 | http://www.w3.org/2000/01/rdf-schema#comment | "Sustained activation of extracellular signal-regulated kinase (ERK) drives pathologies caused by mutations in fibroblast growth factor receptors (FGFRs). We previously identified the inositol phosphatase SHIP2 (also known as INPPL1) as an FGFR-interacting protein and a target of the tyrosine kinase activities of FGFR1, FGFR3, and FGFR4. We report that loss of SHIP2 converted FGF-mediated sustained ERK activation into a transient signal and rescued cell phenotypes triggered by pathologic FGFR-ERK signaling. Mutant forms of SHIP2 lacking phosphoinositide phosphatase activity still associated with FGFRs and did not prevent FGF-induced sustained ERK activation, demonstrating that the adaptor rather than the catalytic activity of SHIP2 was required. SHIP2 recruited Src family kinases to the FGFRs, which promoted FGFR-mediated phosphorylation and assembly of protein complexes that relayed signaling to ERK. SHIP2 interacted with FGFRs, was phosphorylated by active FGFRs, and promoted FGFR-ERK signaling at the level of phosphorylation of the adaptor FRS2 and recruitment of the tyrosine phosphatase PTPN11. Thus, SHIP2 is an essential component of canonical FGF-FGFR signal transduction and a potential therapeutic target in FGFR-related disorders."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.aap8608"xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Trantirek L."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Krejci P."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Erneux C."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Krakow D."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Piskacek M."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Haugsten E.M."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Wesche J."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Fafilek B."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Gudernova I."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Krenova J."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Zieba J.T."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Gregor T."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Varecha M."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Balek L."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Kostas M."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Jonatova L."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Nita A."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Bosakova M.K."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/author | "Cernohorsky N.H."xsd:string |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30228226 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |