| http://purl.uniprot.org/citations/30228260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30228260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30228260 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, here we identify PWWP2A and HDAC2 among the top interactors. PWWP2A and its paralog PWWP2B form a stable complex with NuRD subunits MTA1/2/3:HDAC1/2:RBBP4/7, but not with MBD2/3, p66α/β, and CHD3/4. PWWP2A competes with MBD3 for binding to MTA1, thus defining a new variant NuRD complex that is mutually exclusive with the MBD2/3 containing NuRD. In mESCs, PWWP2A/B is most enriched at highly transcribed genes. Loss of PWWP2A/B leads to increases in histone acetylation predominantly at highly expressed genes, accompanied by decreases in Pol II elongation. Collectively, these findings suggest a role for PWWP2A/B in regulating transcription through the fine-tuning of histone acetylation dynamics at actively transcribed genes."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06235-9"xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-06235-9"xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Wei G."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Wei G."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Fischer R."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Fischer R."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Kessler B.M."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Kessler B.M."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Schwabe J.W.R."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Schwabe J.W.R."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Konietzny R."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Konietzny R."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Brockdorff N."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Brockdorff N."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Millard C.J."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/author | "Millard C.J."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/30228260 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |