| http://purl.uniprot.org/citations/30230404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30230404 | http://www.w3.org/2000/01/rdf-schema#comment | "Objectives: Several schizophrenia brain regions exhibit decreased dysbindin. Dysbindin modulates copper transport crucial for myelination, monoamine metabolism and cellular homeostasis. Schizophrenia patients (SZP) exhibit increased plasma copper, while copper-decreasing agents produce schizophrenia-like behavioural and pathological abnormalities. Therefore, we sought to determine dysbindin and copper transporter protein expression and copper content in SZP.Methods: We studied the copper-rich substantia nigra (SN) using Western blot and inductively-coupled plasma mass spectrometry. We characterised specific protein domains of copper transporters ATP7A, CTR1, ATP7B and dysbindin isoforms 1 A and 1B/C in SZP (n = 15) and matched controls (n = 11), and SN copper content in SZP (n = 14) and matched controls (n = 11). As a preliminary investigation, we compared medicated (ON; n = 11) versus unmedicated SZP (OFF; n = 4).Results: SZP exhibited increased C terminus, but not N terminus, ATP7A. SZP expressed less transmembrane CTR1 and dysbindin 1B/C than controls. ON exhibited increased C terminus ATP7A protein versus controls. OFF exhibited less N terminus ATP7A protein than controls and ON, suggesting medication-induced rescue of the ATP7A N terminus. SZP exhibited less SN copper content than controls.Conclusions: These results provide the first evidence of disrupted copper transport in schizophrenia SN that appears to result in a copper-deficient state. Furthermore, copper homeostasis may be modulated by specific dysbindin isoforms and antipsychotic treatment."xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.org/dc/terms/identifier | "doi:10.1080/15622975.2018.1523562"xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/author | "Roberts R.C."xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/author | "Lapi S.E."xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/author | "Queern S.L."xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/author | "Schoonover K.E."xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/name | "World J Biol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/pages | "13-28"xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/title | "Impaired copper transport in schizophrenia results in a copper-deficient brain state: A new side to the dysbindin story."xsd:string |
| http://purl.uniprot.org/citations/30230404 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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