| http://purl.uniprot.org/citations/30230985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30230985 | http://www.w3.org/2000/01/rdf-schema#comment | "Monocyte chemotactic protein 1 (MCP-1) plays a significant role in inflammation pathways by affecting monocyte/macrophage migration, the number of monocytes and T lymphocytes, and osmosis. Inflammation is closely linked to various types of systematic vasculitis. Here we characterized serum MCP-1 levels in systemic vasculitis patients. This cross-sectional study included serum samples collected from 43 patients with systemic vasculitis and 43 healthy controls (HCs). Serum MCP-1 levels in the samples were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits. Serum MCP-1 levels were significantly higher in patients with systemic vasculitis relative to HCs (parentheses indicate quartile values) [134.65 (73.74, 262.75) pg/mL versus 59.1 (37.41, 90.18) pg/mL, P < 0.001]. Furthermore, systemic vasculitis patients having renal involvement had significantly higher MCP-1 levels relative to patients without renal involvement [196.16 (104.41, 310.35) pg/mL versus 73.74 (41.24, 145.95) pg/mL, P = 0.001] and HCs [196.16 (104.41, 310.35) pg/mL versus 59.10 (37.41, 90.18) pg/mL, P < 0.001]. Serum MCP-1 levels in systemic vasculitis patients were positively correlated with serum creatinine levels (r = 0.387, P < 0.010) and with 24-h proteinuria (r = 0.404, P < 0.014). Receiver operating characteristic (ROC) analysis showed that the cutoff value for MCP-1 to distinguish systemic vasculitis from HCs was 72.73 pg/mg, and the area under the ROC curve was 0.772. The sensitivity and specificity were 76.7% and 72.1%, respectively. Serum MCP-1 levels were significantly higher in patients with systemic vasculitis than in HCs, especially in patients with renal involvement. Thus, serum MCP-1 has the potential to be a biomarker for systemic vasculitis with renal involvement."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.org/dc/terms/identifier | "doi:10.1089/jir.2017.0140"xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Zhu Q."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Zhu B."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Luo Q."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/author | "Liu S.'"xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/pages | "406-412"xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/title | "Increased Serum MCP-1 Levels in Systemic Vasculitis Patients with Renal Involvement."xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/30230985 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30230985 |
| http://purl.uniprot.org/citations/30230985 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30230985 |
| http://purl.uniprot.org/uniprot/#_J3KRT7-mappedCitation-30230985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30230985 |
| http://purl.uniprot.org/uniprot/#_P13500-mappedCitation-30230985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30230985 |
| http://purl.uniprot.org/uniprot/#_Q6UZ82-mappedCitation-30230985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30230985 |
| http://purl.uniprot.org/uniprot/#_V9GZU2-mappedCitation-30230985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30230985 |
| http://purl.uniprot.org/uniprot/V9GZU2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30230985 |
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