| http://purl.uniprot.org/citations/30232010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30232010 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5-/- mice exhibits activated dendritic cells and intrinsic inflammation. Rnf5-/- mice exhibit severe acute colitis following dextran sodium sulfate (DSS) treatment. S100A8 is identified as an RNF5 substrate, resulting in S100A8 ubiquitination and proteasomal-dependent degradation that is attenuated upon inflammatory stimuli. Loss of RNF5 from IECs leads to enhanced S100A8 secretion, which induces mucosal CD4+ T cells, resulting in Th1 pro-inflammatory responses. Administration of S100A8-neutralizing antibodies to DSS-treated Rnf5-/- mice attenuates acute colitis development and increases survival. An inverse correlation between RNF5 and S100A8 protein expression in IECs of IBD patients coincides with disease severity. Collectively, RNF5-mediated regulation of S100A8 stability in IECs is required for the maintenance of intestinal homeostasis."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.08.057"xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Brown K."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Ronai Z.A."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "James B."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Starosvetsky E."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Shen-Orr S.S."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Tessier P.A."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Bradley L.M."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Tinoco R."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Chowers Y."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Sabo E."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Tam M.A."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Bar-Yoseph H."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Gerassy-Vainberg S."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/author | "Khateb A."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/pages | "3296-3311.e6"xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/title | "Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis."xsd:string |
| http://purl.uniprot.org/citations/30232010 | http://purl.uniprot.org/core/volume | "24"xsd:string |