| http://purl.uniprot.org/citations/30232138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30232138 | http://www.w3.org/2000/01/rdf-schema#comment | "B cells undergo epigenetic remodeling as they differentiate into Ab-secreting cells (ASC). LSD1 is a histone demethylase known to decommission active enhancers and cooperate with the ASC master regulatory transcription factor Blimp-1. The contribution of LSD1 to ASC formation is poorly understood. In this study, we show that LSD1 is necessary for proliferation and differentiation of mouse naive B cells (nB) into plasmablasts (PB). Following LPS inoculation, LSD1-deficient hosts exhibited a 2-fold reduction of splenic PB and serum IgM. LSD1-deficient PB exhibited derepression and superinduction of genes involved in immune system processes; a subset of these being direct Blimp-1 target-repressed genes. Cell cycle genes were globally downregulated without LSD1, which corresponded to a decrease in the proliferative capacity of LSD1-deficient activated B cells. PB lacking LSD1 displayed increased histone H3 lysine 4 monomethylation and chromatin accessibility at nB active enhancers and the binding sites of transcription factors Blimp-1, PU.1, and IRF4 that mapped to LSD1-repressed genes. Together, these data show that LSD1 is required for normal in vivo PB formation, distinguish LSD1 as a transcriptional rheostat and epigenetic modifier of B cell differentiation, and identify LSD1 as a factor responsible for decommissioning nB active enhancers."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1800952"xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/author | "Majumder P."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/author | "Boss J.M."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/author | "Randall T.D."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/author | "Haines R.R."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/author | "Scharer C.D."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/author | "Barwick B.G."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/pages | "2799-2811"xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/title | "The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation."xsd:string |
| http://purl.uniprot.org/citations/30232138 | http://purl.uniprot.org/core/volume | "201"xsd:string |
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