| http://purl.uniprot.org/citations/30235477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30235477 | http://www.w3.org/2000/01/rdf-schema#comment | "Sepsis develops because of overwhelming inflammatory responses to bacterial infection, and disrupts vascular integrity. Stabilin-1 (STAB-1) is a phagocytic receptor, which mediates efferocytosis in a phosphatidylserine (PS)-dependent manner. STAB-1 is expected to play important roles in efferocytosis during sepsis. Here, we determined the role of STAB-1 in maintaining and restoring vascular integrity. Macrophages and vascular endothelial cells were used to assess the effect of STAB-1 on survival rate, phagocytic activity, vascular permeability and transendothelial migration (TEM). Additionally, we investigated whether the high-mobility group box 1 (HMGB1)-receptor for advanced glycated end products complex interfered with the binding of Stab1 to PS. Mortality rate was higher in the Stab1-knockout mice than in the wild-type mice, and STAB-1 deficiency was related to reduced macrophage-mediated efferocytosis and the disruption of vascular integrity, which increased vascular permeability, and enhanced TEM. STAB-1 deficiency promoted lung injury, and elevated the expression of sepsis markers. The exogenous application of the anti-HMGB1 neutralizing antibody improved efferocytosis, vascular integrity and survival rate in sepsis. Collectively, our findings indicated that STAB-1 regulated and maintained vascular integrity through the clearance of infected apoptotic endothelial cells. Moreover, our results suggested that interventions targeting vascular integrity by STAB-1 signalling are promising therapeutic approaches to sepsis."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.org/dc/terms/identifier | "doi:10.1055/s-0038-1669477"xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Kim S.Y."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Park E.K."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Lee W."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Kim J.E."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Kim S.W."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Kim I.S."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Yoo Y."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Bae J.S."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/author | "Seo Y.K."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/name | "Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/pages | "1776-1789"xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/title | "Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis."xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/30235477 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30235477 |
| http://purl.uniprot.org/citations/30235477 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30235477 |
| http://purl.uniprot.org/uniprot/#_F7CT68-mappedCitation-30235477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30235477 |
| http://purl.uniprot.org/uniprot/#_E5RKB6-mappedCitation-30235477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30235477 |
| http://purl.uniprot.org/uniprot/#_E5RKB7-mappedCitation-30235477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30235477 |
| http://purl.uniprot.org/uniprot/#_F7BK35-mappedCitation-30235477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30235477 |
| http://purl.uniprot.org/uniprot/#_G3X973-mappedCitation-30235477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30235477 |